I'd start with checking that "/var/run/php5-fpm.sock" does exist as depending on the OS (Unknown) in different places.
Another would be to make sure the php5-fpm service is running.
There is really to little information about the setup to provide much help.
This fixed my problem..
sudo nano /etc/php5/fpm/php.ini
remove comment ;
opcache.enable=0
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